Smiling and alert baby

PreTRM for Healthcare Providers
An Instrumental Prenatal Assessment
For Your Practice

The PreTRM® Test provides you with your patients’ risk for spontaneous premature birth in asymptomatic singleton pregnancies. This pivotal information — provided in the form of an individual risk percentage — gives you sufficient time and vital insights to make informed treatment decisions with your patients.

One in 10 Babies are Born Too Soon

With an incidence of one in ten pregnancies1, preterm birth is considered by many medical experts to be a public health crisis. The emotional, financial, and long-term health implications for preterm babies and their families can be overwhelming. Up until this point, ways to accurately predict the risk of a preterm delivery have been limited, with only a small percentage of high risk patients identified through clinical or demographic risk factors.

Two healthcare workers walking and talking

Limitations of Traditional Preterm Birth Screening Methods

Until recently, clinicians have had limited resources for predicting the risk of spontaneous preterm birth. Traditional indicators of increased risk — such as short cervical length and a positive history for previous spontaneous preterm birth — fail to detect 80% of spontaneous preterm births.2,3

PreTRM researcher looking through her microscope

Answers Provided by Proteomics

Given the limitations of current risk factors to predict the risk of premature birth, scientists at Sera Prognostics set out to discover a biomarker prediction that would provide an early individual risk of assessment for spontaneous preterm birth. Researchers discovered that two proteins combined with biometric variables provides highly accurate prediction of spontaneous preterm birth in asymptomatic singleton pregnancies.

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  1. Hamilton BE, et al. Births: Provisional data for 2020. Vital Statistics Rapid Release; no 12. Hyattsville, MD: National Center for Health Statistics. May 2021.
  2. Petrini JR, et al. Estimated effect of 17 alpha-hydroxyprogesterone caproate on preterm birth in the United States. Obstet Gynecol. 2005;105:267-72.
  3. Hassan SS, et al. Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol. 2011;38:18-31.